Espogen Recombinant Human Erythropoietin Injection

Espogen is a trade name of Recombinant Human Erythropoietin. You can buy Espogen online for treatment of different types of anemia, caused by chronic kidney desease, chemotherapy, surgery etc.

Erythropoietin increases the amount of red blood cell, and accordingly increases the saturation of muscles with oxygen. Since resistance of muscles to fatigue directly depends on oxygen consumption, erythropoieting is widely used in sports as “endurance doping”.

Espogen comes in the form of prefilled syringes with solution for injections. Each syringe contains recombinant human erythropoietin (epoetin alfa). There are different dosages of Espogen - 1000 IU; 2000 IU; 3000 IU; 4000 IU; 6000 IU; 8000 IU; 10000 IU.

How EPO works

Erythropoietin is a powerful glycoprotein hormone,whichstimulates thecreation of erythrocytes in the bone marrow.By binding to specific receptors, EPOtransforms mature progenitor cells into proerythroblasts. Besides, it activates the synthesis of hemoglobin and other proteins found in normal erythroblasts.

The amino acid sequence and pattern of glycosylation ofRecombinant Erythropoietin Alpha is identical to endogenous human erythropoietin. Therefore,recombinant human erythropoietin has the same biological activity as natural EPO.

In adults, almost 90% of EPO is produced in kidneys and the rest in the liver. In normal conditionsthe formation of endogenous erythropoietin is regulated by the level of tissue oxygenation.

In a healthy organism,the levels of plasma erythropoietin vary from 0.01 to 0.03 U / ml and increase 100–1000 times in case of hypoxia and anemia. Thus,hypoxia and anemia increase the formation of erythropoietin, which in turn stimulates theformation of red blood cells.

Since erythroid precursors require several days to mature, a clinically significant increase of hematocrit will be in 2 weeks of therapy. In some cases it takes up to 6 weeks. Due to this delay of effect, one should be very careful while increasing the dose. Moreover, doctors do not recommend using erythropoieting for more than 6 weeks.

Pay attention that erythropoietin may fail to work in case of iron or vitamin B12 deficiency, and some pathological conditions, such as hypothyroidism, chronic inflammation etc.

How to use EPO safely

One should remember that increased amount of erythrocytes leads to high viscosity of the blood. This in turn increases the risk of thrombosis, heart attack and stroke, which can be lethal. Therefore, do not increase the dose without necessity and always control your blood counts.

The usual weekly dose of Espogen is 50-300 IU per kilogram of body weight (kbw), which should be split into 3 equidistant injections. Remember that smaller regular injections are better than single big one, since it is more natural for the organism and reduce detectability.

The usual EPO cycle is the following:

Week 1-3 loading phase 4500-12000 IU (6000 IU in average)

Week 4-6supportive phase 3000-4000 IU

Alternatively, you can use 20-30 IU/kbw per injection (three injections a week). There is also conservative scheme - 4500 IU / week (3 injections by 1500 IU) for loading phase, and 3000 IU / week for supportive phase (3 injections by 1000 IU).

Remember that higher doses are more effective, however they increase the risks of side effects and detectability in doping tests.

You can reduce viscosity of the blood and risk of thrombosis by taking aspirin 2 times a day. However, in case of high doses you should take more powerful anticoagulants.

Also, note that half-life of EPO depends on the type of administration. In case of intravenous injection the half-life is 4-5 hours, whereas in case of subcutaneous injection it will be about 24 hours. Therefore, you should complete you EPO cycle few days before the competition.